Development of chemical exchange saturation transfer at 7T
نویسندگان
چکیده
منابع مشابه
Analytical determination of the chemical exchange saturation transfer (CEST) contrast in molecular magnetic resonance imaging
Magnetic resonance based on molecular imaging allows tracing contrast agents thereby facilitating early diagnosis of diseases in a non-invasive fashion that enhances the soft tissue with high spatial resolution. Recently, the exchange of protons between the contrast agent and water, known as the chemical exchange saturation transfer (CEST) effect, has been measured by applying a suitable pulse ...
متن کاملpCEST: Positive contrast using Chemical Exchange Saturation Transfer.
Chemical Exchange Saturation Transfer (CEST) contrast utilizes selective pre-saturation of a small pool of exchanging protons and subsequent detection of the decrease in bulk water signal. The CEST contrast is negative and requires detection of small signal change in the presence of a strong background signal. Here we develop a Positive CEST (pCEST) detection scheme utilizing the analogous natu...
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Molecular imaging research has shown great potential to assess the molecular compositions of tissues and provide critical information for clinical diagnoses [1]. These noninvasive assessments of molecular compositions may provide earlier diagnoses of pathologies, may predict therapeutic effects before the therapy is initiated and may provide earlier assessments of therapeutic effects soon after...
متن کاملSimulation and Optimization of Pulsed Chemical Exchange Saturation Transfer for Clinical Application at 3T
Chemical Exchange Saturation Transfer (CEST) is often overlooked as a method for the investigation of metabolites in vivo due to the time required to obtain a full spectrum. We investigated the feasibility and optimization of a pulsed CEST technique that interleaves an echo planer imaging (EPI) readout with saturation in order to reduce time. In addition, we incorporated a multi-shot EPI sequen...
متن کاملOn the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4 T.
Chemical exchange saturation transfer (CEST) provides an indirect means to detect exchangeable protons within tissues through their effects on the water signal. Previous studies have suggested that amide proton transfer (APT) imaging, a specific form of CEST, detects endogenous amide protons with a resonance frequency offset 3.5 ppm downfield from water, and thus may be sensitive to variations ...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2011
ISSN: 0740-3194
DOI: 10.1002/mrm.22862